中药制剂不良反应分析与对策

目的：分析中药制剂的不良反应，并研究有效的预防对策。方法：随机选择2008年1月-2012年12月之间，我院因中药制剂引发不良反应导致住院治疗的患者60例，对所有患者的年龄、性别、药品种类、不良反应表现、不良反应引发原因等进行统计、比较和分析，并研究和提出相应的临床解决对策。结果：经过统计学分析显示，在60例患者中，男24例（40.0%），女36例（60.0%）；口服制剂8例（13.3%），注射制剂47例（78.3%），外用制剂5例（8.4%）；累及皮肤及附件29例（48.3%），消化系统12例（20.0%）；不合理配伍31例（51.7%），选药不当12例（20.0%）。结论：中药制剂不良反应人群以女性和老年患者居多，主要为注射剂，多表现为皮肤及附件反应，不良反应发生原因主要为药物不合理配伍，临床中要针对上述特点合理选择和使用中药制剂。

An analysis and countermeasures of adverse reactions in TCM medicine

Objective：To analyze adverse reactions of TCM medicine and research for an effective solution. Methods：Age, gender, types of drugs, adverse reactions performance of 60 patients were recorded and compared, a clinical solution should be proposed to resolve it. Results： In 60 patients, 24 patients （40.0%） were male, 36 patients （60.0%） were female; 8 cases （13.3%） were caused by oral preparations, 47 cases （78.3%） were caused by injection preparations, 5 cases （8.4%） were caused by topical preparations;29 cases （48.3%） involve with the skin and accessories, 12 cases （20.0%） involve with the digestive system;the reason of adverse reactions was unreasonable compatibility of 31 cases （51.7%）, and improper drug selection of 12 cases（20.0%）. Conclusion：Adverse reactions of TCM medicine were common in women and the senile; the main reason of it was unreasonable compatibility, rational selection and application of TCM medicine should be paid attention in clinic.