肝素与低分子肝素治疗急性早幼粒细胞白血病合并弥漫性血管内凝血的疗效比较

目的观察肝素与低分子肝素治疗急性早幼粒细胞白血病(APL)合并弥漫性血管内凝血(DIC)的疗效对比。方法56例APL合并DIC患者,随机分为肝素治疗组(28例)和低分子肝素治疗组(28例),分别给予肝素8mg,每8h1次,iH和低分子肝素0.4mL,1次/d,iH治疗,同时积极治疗原发病并补充凝血因子。结果肝素治疗组和低分子肝素治疗组使用抗凝剂的时间分别为(11.4±3.6)d和(10.1±3.0)d,两组比较,无显著性差异(P>0.05)。两组治愈率分别为92.9%和96.4%,无显著性差异(P>0.05)。结论肝素和低分子肝素治疗APL合并DIC同样有效,治愈率高,副作用轻微。

Therapeutic effect of heparin and low-molecular-weight heparin (LMWH) on patients with acute promyelocytic leukemia(APL) complicated with disseminated intravascular coagulation

Objective To observe the therapeutic effect of heparin and low-molecular-weight heparin(LMWH) on patients with acute promyelocytic leukemia(APL) complicated with disseminated intravascular coagulation(DIC).Methods Fifty-six patients with APL complicated with DIC were divided into heparin group(28 cases) and LMWH group(28 cases) randomly,and respectively received heparin of 8 mg q8 h,iH and LMWH of 0.4 mL,qd,iH,and at the same time,the patients also received treatment for primary diseases and administration of coagulatory factors.Results The therapeutic time of heparin group and LMWH group were (11.4±3.6)days and (10.1±3.0)days respectively (P>0.05).The cure rate were 92.9% and 96.4% respectively(P>0.05).Conclusion Both heparin and LMHW can receive high cure rate in treatment for APL complicated with DIC,and side effect of them was mild.