牙周炎对2型糖尿病患者血清C反应蛋白水平的影响

目的 探讨牙周感染对2型糖尿病患者血清C反应蛋白（CRP）水平的影响。方法 选择伴重度慢性牙周炎的2型糖尿病患者32例为试验组，以年龄（±3岁）、性别、体重指数（±1 kg/m2）配比单纯2型糖尿病患者32例为对照组。采用超敏CRP酶联免疫法测定所有患者的血清CRP水平。结果 试验组患者血清CRP水平平均为3.07 mg/L，对照组为1.78 mg/L，试验组高于对照组（P<0.05）；试验组血清CRP≥3.0 mg/L的患者占53.13％，对照组为28.13％，试验组高于对照组（P<0.05）。结论 牙周感染可升高2型糖尿病患者血清CRP水平，这种炎性因子的升高可能会加重胰岛素抵抗，增加2型糖尿病患者大血管并发症的危险性。

Effect of Periodontitis on Circulating C-reactive Protein in Type 2 Diabetes Patients

OBJECTIVE: To investigate the effect of periodontal infection on circulating C-reactive protein (CRP) in type 2 diabetes patients. METHODS: 32 diabetes patients with advanced periodontitis participated in this study. They were compared to a group of 32 diabetes patients without periodontal disease, who were mathed with regard to age (+/- 3 years), gender and body mass index (+/- 1 kg/m2). The concentration of CRP on circulation was measured by ELISA. RESULTS: Significant difference was found in the level of CRP and the percentage of subjects with elevated CRP levels > or = 3 mg/L on circulation between the two groups(P < 0.05). CONCLUSION: Periodontal infection results in higher circulating CRP in type 2 diabetes patients. This elevated inflammatory factor may exacerbate insulin resistance and increase the risk for great vessels complications of diabetes mellitus.