Biosynthesis of renal prostaglandins in spontaneously hypertensive rats

The biosynthesis of prostaglandins (PG) E₂ and F₂ from [¹⁴C]arachidonic acid by renal medullary tissue of rats with spontaneous hypertension and of normotensive Wistar rats was investigated at different ages (1.5 and 3.5 months). In animals with spontaneous hypertension the synthesis of PG E₂ from arachidonic acid was at a much lower level than in Wistar rats. The biosynthesis of PG F₂ in these animals was virtually indistinguishable from normal. No age differences were found in PG formation by the kidneys of rats with spontaneous hypertension, whereas in Wistar rats PG E₂ biosynthesis was depressed at the age of 3.5 months.Laboratory of Pathophysiology, Institute of Pediatrics, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of medical Sciences of the USSR A. M. Chernukh.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 6, pp. 659–661, June, 1977