Direct human papillomavirus e6 whole-cell enzyme-linked immunosorbent assay for objective measurement of e6 oncoproteins in cytology samples |
| |
Authors: | Yi-Shan Yang Karen Smith-McCune Teresa M Darragh Yvonne Lai Ju-Hwa Lin Ting-Chang Chang Hsiao-Yun Guo Tiea Kesler Alicia Carter Philip E Castle Shuling Cheng |
| |
Institution: | OncoHealth Corporation, Fremont, California, USA. |
| |
Abstract: | A novel, whole-cell enzyme-linked immunosorbent assay (ELISA) based on a non-type-specific anti-human papillomavirus (HPV) E6 antibody was tested on 182 residual cytological specimens. For samples with a designation of more severe than cervical intraepithelial neoplasia grade 3 (CIN3+), 83% tested positive for E6; in a subset with paired testing for E6 ELISA and HPV DNA, 72% tested E6 positive and 92% tested high-risk (HR)-HPV DNA positive (P = 0.2). Among the women with a less than CIN3 diagnosis, 31% and 47% tested positive for E6 and HR-HPV DNA, respectively (P = 0.0006). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|