| 纤维素硫酸酯体内抗凝血活性的实验研究 |
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| 引用本文： | 王兆梅,李琳,蔡妙颜,桂林. 纤维素硫酸酯体内抗凝血活性的实验研究[J]. 中国新药杂志, 2005, 14(8): 992-994 |
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| 作者姓名： | 王兆梅 李琳 蔡妙颜 桂林 |
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| 作者单位： | 华南理工大学食品与生物工程学院,广州,510640 |
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| 基金项目： | 广东省自然科学基金资助项目（000453） |
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| 摘 要： | 目的:研究纤维素硫酸酯对动物体内的抗凝血活性。方法:用试管法测凝血时间(CT),用凝固法测定活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和凝血酶时间(TT),以肝素和硫酸化右旋糖酐为阳性对照,考察其抗凝血活性的量效性和时效性。结果:纤维素硫酸酯能显著延长CT,APTT和TT,且呈剂量依赖性,但在所试剂量范围内对PT无明显影响;其抗凝血活性在给药2h时达到最大。结论:纤维素硫酸酯具有明显抗凝血作用,强于现有同类抗凝血药硫酸化右旋糖酐,略低于150IU·mg-1的肝素。
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| 关 键 词： | 纤维素硫酸酯 抗凝血活性 大鼠 |
| 文章编号： | 1003-3734（2005）08-0992-03 |
| 收稿时间： | 2005-03-10 |
| 修稿时间： | 2005-03-10 |
Anticoagulant activity of cellulose sulfate in vivo |
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| WANG Zhao-mei,LI Lin,CAI Miao-yan,GUI Lin. Anticoagulant activity of cellulose sulfate in vivo[J]. Chinese Journal of New Drugs, 2005, 14(8): 992-994 |
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| Authors: | WANG Zhao-mei LI Lin CAI Miao-yan GUI Lin |
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| Abstract: | Objective:To assess the anticoagulant activity of cellulose sulfate in vivo .Methods:Coagulation time (CT) was measured using a test tube method. Activated partial thromboplastin time (APTT), thrombin time (TT), and pro-thrombin time (PT) were monitored via a coagulation method. Heparin and dextran sulfate were used as positive controls.Results:CT, APTT and TT were significantly prolonged by cellulose sulfate in a dose-dependent manner. No significant difference in PT was observed. The maximal anticoagulant potency achieved in 2 hours after the administration of cellulose sulfate.Conclusion:Cellulose sulfate presents an obvious anticoagulant activity.The anticoagulant potency of cellulose sulfate was more powerful than dextran but less than heparin of 150 IU/mg. |
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| Keywords: | cellulose sulfate anticoagulant activity rats |
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