739例心血管类药物不良反应分析

目的:调查心血管类药物ADR的临床特点及产生原因。方法:从1998年～2001年4月公开发行的国内70余种医药学期刊中收集到心血管类药物不良反应个案776例,其中符合药物不良反应判定标准的739例,按照不良反应类别进行归纳、统计和分析。结果:心血管类药物的不良反应共涉及人体7个系统,其中呼吸系统所占的比例最大(29.8%);涉及相关药物六大类,以ACEI类药物较为常见(230例);重度不良反应46例,死亡15例,死亡占2.03％;51岁以上年龄组的不良反应(78.9％)高于其 他年龄组;口服给药(65.5％)较其他给药途径发生的比例高。结论:心血管类药物ADR的发生与药物的药理作用、给药途径、合并用药及患者的年龄、个体差异、饮食习惯等有关。

Analysis of adverse reactions to cardiovascular drugs in 739 cases

Objective: To specify clinical characteristics and causes of adverse reactions to cardiovascular drugs. Method: 739 adverse reactions to cardiovascular drugs were collected and analyzed from domestic articles in 1998-2001. Results: Adverse reactions to cardiovascular drugs occurred in the body's seven systems, with respiratory system in the highest proportion(29.8%) . Six groups of drugs were involed and ACEI was the main one for causing ADR (230 cases) . As for ADR intensity, severe reactions were showed in 46 cases, among them 15 deaths. Most of ADR were caused by oral administration(65.5%) and in age of 51 and upwards (78.9%). Conclusion:The occurrence of adverse reactions to cardiovascular drugs was related to drugs' pharmacology, route of administraction, interactions and patients' age, individual difference.