| 卵巢上皮性肿瘤的雌、孕激素受体定位研究 |
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| 引用本文： | 王素霞,唐素恩.卵巢上皮性肿瘤的雌、孕激素受体定位研究[J].北京大学学报(医学版),1991(5). |
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| 作者姓名： | 王素霞 唐素恩 |
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| 作者单位： | 北京医科大学第一医院电镜室
(王素霞)，北京医科大学第一医院电镜室(唐素恩) |
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| 摘 要： | 本文对19例卵巢不同类型的上皮性肿瘤进行了雌激素受体(ER)及孕激素受体(PR)的免疫定位研究。ER、PR的分布方式有三种:腔膜型、弥散型及核主型。浆液性癌以腔膜型分布为主,宫内膜样癌多呈弥散型及核主型分布;2例分泌型宫内膜样癌(透明细胞癌)的孕激素受体均呈核主型分布,且呈明显强阳性。ER、PR的定位研究较生化法更直接地反映了雌、孕激素与卵巢肿瘤的关系,对临床内分泌治疗具有重要指导意义。
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| 关 键 词： | 卵巢 上皮性肿瘤 雌激素受体 孕激素受体 定位 |
ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR LOCALIZATION IN OVARIAN EPITHELIAL TUMORS |
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| Wang Suxia,Tang Suen.ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR LOCALIZATION IN OVARIAN EPITHELIAL TUMORS[J].Journal of Peking University:Health Sciences,1991(5). |
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| Authors: | Wang Suxia Tang Suen |
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| Institution: | Wang Suxia,Tang Suen Department of Electron Microscope,The First School of Clinical Medicine |
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| Abstract: | Estrogen receptor (ER) and Progesterone receptor (PR) were identified in 19 ovarian epithelialtumors by immunohistochmical technique. According to the reaction products distribution, we describedthe localization of ER and PR as three patterns: Luminal membranous, diffuse, and nucleusdominative type. Most serous carcinomas were stained in luminal membranous type. But endometroidcarcinomas expressed mainly diffuse and nucleus dominative types. Two cases of endometroidcarcinoma secretary type (clear cell carcinoma) demonstrated strong positive PR reaction located innucleus dominative type. The immunohistochemical study of ER and PR in ovarian carcinomasreflected the relations between estrogen or progesterone hormones and ovary tumors more directly thanthe biochemical assays, and may serve as an important guide for the endocrine therapy. |
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| Keywords: | Epithelial tumors Ovary receptor immunolocalization Estrogen receptor Progesterone receptor |
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