| 川芎素对大鼠脑缺血再灌注时突触后致密物质-95活性的影响 |
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| 引用本文： | 陈绍洋,王强,熊利泽,金卫林,董辉,刘艳红.川芎素对大鼠脑缺血再灌注时突触后致密物质-95活性的影响[J].第四军医大学学报,2002,23(12):1150-1152. |
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| 作者姓名： | 陈绍洋 王强 熊利泽 金卫林 董辉 刘艳红 |
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| 作者单位： | 1. 第四军医大学:西京医院麻醉科,陕西,西安,710033
2. 第四军医大学:全军神经科学研究所,陕西,西安,710033 |
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| 基金项目： | 国家自然科学基金，01M118， |
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| 摘 要： | 应用神经行为学评估、脑梗死容积测量和Western blot分析,探讨研究阿魏酸钠(SF)的神经保护作用及其对局灶性脑缺血损伤时突轴后致密物质-95(PSD-95)活性的影响,证实SF明显改善再灌注24 h神经功能缺陷和减少脑梗死容积,显著增强再灌注后PSD-95表达,表明SF可能通过加强PSD-95活性来改善缺血性损伤.
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| 关 键 词： | 注射用川芎素 脑缺血 突触后致密物质－95 |
Effect of sodium ferulate on activation of postsynaptic density-95 after transient cerebral artery occlusion in the rat brain |
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| Abstract.Effect of sodium ferulate on activation of postsynaptic density-95 after transient cerebral artery occlusion in the rat brain[J].Journal of the Fourth Military Medical University,2002,23(12):1150-1152. |
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| Authors: | Abstract |
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| Abstract: | To investigate the neuroprotective efficacy of sodium ferulate (SF), and the effects of SF on expression of postsynaptic density-95 (PSD-95) in rat brain following transient focal cerebral ischemic injury using neurobehavioral evaluation, infarct volume assessment and Western blot analysis. It was confirmed that SF could significantly improve neurologic function deficit, reduce cerebral infarct volume at 24 h after reperfusion, and markedly potentiate expression of PSD-95 after reperfusion, which implies SF can alleviate cerebral ischemic damages probably via enhancing activation of PSD-95. |
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| Keywords: | postsynaptic density-95 sodium ferulate cerebral ischemia |
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