| 缬沙坦联合琥珀酸美托洛尔治疗慢性心力衰竭临床疗效观察 |
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| 引用本文： | 阚国庆,黄孟洪,李争,王德启,王继征,白娟,李广军.缬沙坦联合琥珀酸美托洛尔治疗慢性心力衰竭临床疗效观察[J].中国当代医药,2010,17(27):70-72. |
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| 作者姓名： | 阚国庆 黄孟洪 李争 王德启 王继征 白娟 李广军 |
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| 作者单位： | 山东省枣庄矿业集团枣庄医院,山东枣庄,277101 |
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| 摘 要： | 目的：探讨缬沙坦联合琥珀酸美托洛尔对慢性充血性心力衰竭（CHF）的临床疗效。方法：将98例CHF患者随机分为治疗组（50例）和对照组（48例）,对照组予以洋地黄、血管紧张素转换酶抑制剂（ACEI）、琥珀酸美托洛尔、利尿剂等综合治疗;治疗组在对照组治疗基础上,ACEI改用缬沙坦,两组疗程均为12个月。观察治疗前后血压、心率及超声心动图测定心功能指标的变化。结果：治疗组血压及心率下降程度、6min步行距离,以及左心室内径缩短程度、左室射血分数、相对室壁厚度（RWT）、短轴缩短率（FS）、心搏出量（SV）增加程度均显著优于对照组（P〈0.05）。结论：缬沙坦联合琥珀酸美托洛尔能够更好地逆转左心室肥厚及增加左室射血分数,改善心功能。
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| 关 键 词： | 缬沙坦 琥珀酸美托洛尔 心力衰竭 充血性 |
Efficacy of vasartan combined with metoprolol in treatment of congestive heart failure |
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| Authors: | KAN Guoqing HUANG Menghong LI Zheng WANG Deqi WANG Jizheng BAI Juan LI Guangjun |
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| Institution: | (Zaozhuang Hospital of Zaozhuang Mining Group,Shandong Province,Zaozhuang 277101,China) |
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| Abstract: | Objective：To observe the efficacy of vasartan combined with metoprolol on congestive heart failure （CHF）. Methods：A total of 98 patients with CHF were randomly divided into clinical group （n=50） and control group （n=48）.The treating course of two groups both was 12 months. The clinical therapeutic efficacy （BP,HR）and left ventricular internal diameter （LVD）,left ventricular ejection fraction （LVEF）,relative wallthickness （RWT）,fractionshortening （FS）,sendout volume （SV）,and adverse reactions were analyzed.Results：The clinical therapeutic efficacy （BP,HR）,LVD,LVEF,RWT,FS,SV,after treatment in observation group were more ameliorated than those of control group （P0.05）.Conclusion：Vasartan combined with metoprolol can reverse left ventricular hypert rophy,increase LVEF and improve heart function. |
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| Keywords: | Vasartan Metoprolol Heart failure Congestive |
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