| 沉降法制备新型聚氨酯血液相容性材料 |
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| 引用本文： | 何承爱,邱化廷,邵晓林,魏云峰,章峻.沉降法制备新型聚氨酯血液相容性材料[J].医学教育探索,2012,25(3). |
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| 作者姓名： | 何承爱 邱化廷 邵晓林 魏云峰 章峻 |
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| 作者单位： | 南京师范大学，江苏生物功能材料重点实验室，南京 210097;南京师范大学，江苏生物功能材料重点实验室，南京 210097;南京师范大学，江苏生物功能材料重点实验室，南京 210097;南京师范大学，江苏生物功能材料重点实验室，南京 210097;南京师范大学，江苏生物功能材料重点实验室，南京 210097 |
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| 基金项目： | 国家自然科学基金(20874047)；江苏省自然科学基金(08KJB150010) |
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| 摘 要： | 采用一种新型聚氨酯纳米微球（PUI-NPs）修饰聚氨酯（PU）薄膜，利用沉降法制备出具有良好血液相容性的聚氨酯/聚氨酯纳米微球(PU/PUI-NPs)。以扫描电镜、红外光谱、X射线光电子能谱对PU/PUI-NPs膜表面结构进行表征。以血小板黏附、复钙、溶血和蛋白吸附实验对PU/PUI-NPs膜的血液相容性进行了表征。结果表明:PUI-NPs已被成功引入PU膜表面，PU/PUI-NPs膜的血液相容性比PU有显著的提高,相比于PU,PU/PUI-NPs膜的细胞毒性更低。
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| 关 键 词： | 聚氨酯纳米微球 聚氨酯 表面改性 血液相容性 |
| 收稿时间： | 2012/6/12 0:00:00 |
Preparation of New Blood Compatible Polyurethane Materials with Sedimentation |
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| HE Cheng-ai,QIU Hua-ting,SHAO Xiao-lin,WEI Yun-feng and ZHANG Jun.Preparation of New Blood Compatible Polyurethane Materials with Sedimentation[J].Researches in Medical Education,2012,25(3). |
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| Authors: | HE Cheng-ai QIU Hua-ting SHAO Xiao-lin WEI Yun-feng and ZHANG Jun |
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| Affiliation: | Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China;Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China;Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China;Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China;Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China |
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| Abstract: | A kind of novel polyurethane ionomer nanoparticles (PUI-NPs) were used to modify polyurethane (PU) films. An excellent blood compatible polyurethane/polyurethane ionomer nanoparticles composite film (PU/PUI-NPs film) was prepared with sedimentation. The structure of the PU/PUI-NPs film was characterized with SEM, ATR-FTIR and XPS. Platelet adhesion, recalification time, hemolysis and protein adsorption measurement were used to assess the blood compatibility of PU/PUI-NPs film. Results showed that PUI-NPs was introduced into the PU surface successfully. The blood compatibility of PU/PUI-NPs film was improved remarkably, compared with that of PU. PU/PUI-NPs film had lower cytotoxicity than PU. |
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| Keywords: | PUI-NPs PU surface modification blood compatibility |
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