类天疱疮样扁平苔藓1例

目的：报告和分析一例少见的类天疱疮样扁平苔藓病例。方法：取患背部皮损活检组织部分行组织病理和免疫病理检查。结果：活检组织切片，HE染色示：表皮角化过度伴角化不全，颗粒层不规则增厚，基底细胞液化严重已融合成表皮下大疱，无大疱区域表皮和真皮分界不清。有较多淋巴细胞在此区域以及血管周浸润，可见“色素失禁”现象。直接免疫荧光显示基底膜有IgG、C3、IgM呈线状沉积。符合类天疱疮样扁平苔藓。经治疗后痊愈，随访一年未见复发。结论：类天疱疮样扁平苔藓临床表现和病理结果不同于大疱性扁平苔藓和大疱性类天疱疮，是一个独立的疾病。可采用灰黄霉素、四环素和烟酰胺治疗。

Lichen Planus Pemphigoides(LPP) - A Case Report.

Objective:We report a rare case of lichen planus pemphigoides.Methods: Biopsy spci-men from the skin lesion on the back was taken for pathology and immunopathology examination. Results : H. E. stain of biopsy specimen revealed that hyperkeratosis and parakeratosis in epidermis, and anomalous thickening in granular layer, and serious liquefaction of basal cell, and incontinence of pigmentation. Direct immunofluorescence revealed linear C3 and IgG deposition in basement membrane zone(BMZ). The symptom was disappered and does not relapse in a year. Conclusion: Lichen planus pemphigoides is different from bullous lichen palnus and bullous pemphigoid. Treatment of the patient with fulvicin, tetracycline and niacinamide was good response.