Is the CACNA1A gene involved in familial migraine with aura? |
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Authors: | R Brugnoni M Leone A Rigamonti E Moranduzzo F Cornelio R Mantegazza G Bussone |
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Institution: | (1) Department of Neuromuscular Diseases, C. Besta National Neurological Institute, Milan, Italy, IT;(2) Headache Center, C. Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, Italy, IT |
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Abstract: | The discovery of mutations in the neural calcium channel (CACNA1A) gene in familial hemiplegic migraine (FHM), variant of
migraine with aura, led to the suggestion that this gene might be involved in familial migraine with aura (FMA). We investigated
whether the mutations in FHM are present in FMA patients, analyzing genomic DNA by PCR, single stranded conformation polymorphism,
sequencing and restriction enzyme. No mutations were found. A known polymorphism (5682–14C>T) was found in exon 36. These
findings suggest that the mutations found in FHM and the other known mutations of the CACNA1A gene are not the genetic basis
of FMA. Genetic alterations in FMA patients may be localized on chromosome 19 but not in the CACNA1A exons we investigated.
Received: 25 January 2002 / Accepted in revised form: 25 February 2002 |
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Keywords: | Migraine with aura Familial hemiplegic migraine CACNA1A gene Mutation |
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