| 周剂量CPT-11治疗FOLFOX治疗失败的转移性结直肠癌 |
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| 引用本文： | 张斌.周剂量CPT-11治疗FOLFOX治疗失败的转移性结直肠癌[J].医药论坛杂志,2009(4). |
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| 作者姓名： | 张斌 |
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| 作者单位： | 夏邑县人民医院肿瘤科; |
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| 摘 要： | 目的观察和评价依立替康(CPT-11)联合5-FU/LV治疗FOLFOX治疗失败的转移性结直肠癌的疗效及不良反应。方法入组患者共34例为转移性结直肠癌,经草酸铂及5-FU/LV治疗失败后,予CPT-11 60mg/m2,LV100mg/m2,5-FU 500mg/m2,每周1次,连续3周,每4周重复。患者最多接受6个周期,每例至少2周期化疗后评价疗效。结果全组34病例均可评价。PR为5例,SD为17例,有效率14.7%(95%可信区间3.6%～34.4%),疾病控制率64.7%(95%可信区间46.8%～85.6%),平均TTP为3.5个月(范围1.5～7.5个月)。主要不良反应为白细胞减少,恶心呕吐,手足综合征及延迟性腹泻,其不良反应发生率分别为67.4%(23/34),61.8%(21/34),64.8%(22/34),38.2%(13/34),均无IV度不良反应。结论周剂量伊立替康联合5-FU/LV为草酸铂治疗失败的转移性结直肠癌挽救治疗方案,不良反应轻微,适合于曾经强烈化疗患者。
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| 关 键 词： | 伊立替康 联合化疗 转移性结直肠癌 |
Effect of Weekly Chemotherapy Based on CPT-11 on FOLFOX Failure in Patients with Metastasis Colorectal Cancer |
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| ZHANG Bin Xiayi Peoplie's Hospital,Xiayi ,China.Effect of Weekly Chemotherapy Based on CPT-11 on FOLFOX Failure in Patients with Metastasis Colorectal Cancer[J].Journal of Medical Forum,2009(4). |
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| Authors: | ZHANG Bin Xiayi Peoplie's Hospital Xiayi China |
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| Institution: | ZHANG Bin Xiayi Peoplie's Hospital,Xiayi 476400,China |
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| Abstract: | Objective To evaluate the clinical efficacy and adverse effects of irinotecan(CPT-11) combined with 5-Fu /LV after FOLFOX failure in patients with metastasis colorectal cancer.Methods Total 34 patients with metastasis colorectal cancer,who were failed in being treated with platinum oxalate and 5-Fu /LV,received 4 week regimen: CPT-11 60mg/m2 ivgtt d1,8,15,LV 100mg/m2 ivgtt d1,8,15,5-FU 500mg/m2 ivgtt d1,8,15;a cycle was 28 days.The cycle was not more than six.Results Total 34 cases could evaluate efficacy,t... |
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