盐酸右美托咪定在危重症患者机械通气的临床研究

目的探讨盐酸右美托咪定对危重症患者机械通气的临床效果。方法选择我院于2012年1月～2013年7月人住重症监护病房（ICU）的需要机械通气的120例危重症患者，将其随机地分为治疗组和对照组，治疗组60例，给予盐酸右美托咪定镇静治疗；对照组60例，给予咪达唑仑镇静治疗。记录两组患者镇静中各时点的呼吸、循环、镇静指标及机械通气总时间、入住ICU时间，进行对比分析。结果治疗组的呼吸、循环等指标均好于对照组，同时治疗组患者的Ramsay评分、机械通气总时间、入住ICU时间均明显少于对照组，且两组间的差异具有统计学意义（P〈0．01）。结论盐酸右美托咪定治疗相比咪达唑仑治疗的镇静效果更好，安全性高，具有重要的临床应用价值。

Clinical study of dexmedetomidine hydrochloride in mechanical ventilation for critical patients

Objective To investigate clinical effect of dexmedetomidine hydrochloride in mechanical ventilation for critical patients. Methods 120 cases of critical patients requiring mechanical ventilation in our ICU from January 2012 to July 2013 were divided into the treatment group（60）,treated by dexmedetomidine hydrochloride and the control group （60）,treated by midazolam.The breathing,circulation,calm indicators,total time of mechanical ventilation,ICU stay of two groups were analyzed. Results After treatment,the respiratory, circulatory and other indicators of the treatment group were better than that of the control group,while the Ramsay score,the total duration of mechanical ventilation and ICU stay of the treatment group were significantly less than that of the control group,with the significant difference （P 〈 0.01 ）. Conclusion Compared to midazolam sedation treatment,dexmedetomidine hydrochloride in treatment for critical patients has better,safe,important clinical value.