胃镜下注射去甲肾上腺素联合奥美拉唑治疗消化性溃疡出血的疗效观察

目的探讨胃镜下注射去甲肾上腺素联合奥美拉唑治疗消化性溃疡出血的疗效及安全性。方法将82例消化性溃疡出血患者随机分为观察组和对照组，每组各4l例。观察组采用胃镜下注射去甲肾上腺素联合奥美拉唑治疗，对照组采用奥美拉唑联合立止血治疗。结果观察组总有效率明显高于对照组，两组比较差异有统计学意义（P〈0．05）；两组患者24h、48h及72h空腹胃液pH值逐渐升高，与治疗前相比有统计学意义（P〈0．05），且观察组升高幅度明显优于对照组（P〈0．05）；观察组患者止血时间、输液时间、住院时间均明显低于对照组（P〈0．05），输血量及住院费用较对照组明显减少（P〈0．05），再出血发生率明显低于对照组（P〈0．05）。两组均未见明显不良反应。结论胃镜下注射去甲肾上腺素联合奥美拉唑治疗消化性溃疡出血疗效确切，安全可靠，值得临床推广应用。

Clinical observation of endoscopic injection of norepinephrine combined with omeprazole in patients with peptic ulcer bleeding

Objective To evaluate the efficacy and safety of injection of norepinephrine under gastroscope combined with Omeprazole in Peptic Ulcer bleeding. Methods 82 case of Peptic Ulcer bleeding patients were randomly divided into observation group and control group, 41 cases in each group. The observation group received endoscopic injection of norepinephrine and omeprazole combined treatment, and the control group received treatment of reptilase combined with omeprazole. Results The total effective rate of observation group was significantly superior to that of control group, and the difference was statistically significant（P 〈 0.05）; Two groups of patients, 24 h, 48 h and 72 h after the treatment, the pH value on an empty stomach gastric juice were gradually elevated, there were statistically significant difference between before and after the treatment（P 〈 0.05）, and the observation group was obviously better than the control group（P 〈 0.05）; Observation group of patients stop bleeding time, transfusion time, length of hospital stay were significantly lower than the control group（P 〈 0.05）, blood transfusion and hospitalization cost were decreased significantly（P 〈 0.05）, and incidence of bleeding again significantly was significantly lower than the control group（P 〈 0.05）. In the two groups were not seen obvious adverse reactions. Conclusion Endoscopic injection of norepinephrine combined with omeprazole in patients with Peptic Ulcer bleeding is effective, Safe and reliable, it is worthy to be popularized.