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The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene |
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| Authors: | Mugneret F Chaffanet M Maynadié M Guasch G Favre B Casasnovas O Birnbaum D Pébusque M J |
| Affiliation: | Laboratoires de Cytogénétique et d'Hématologie, Hématologie clinique, H?pital du Bocage, Dijon, France. |
| Abstract: | Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner. |
| Keywords: | myeloproliferative disorder translocation FGFR1 gene chromosome 8 chromosome 19 |
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