| PICK1在伏隔核突触传递中的作用 |
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| 引用本文： | 蔡飞,王江华,吴迪,沈略,张俊杰.PICK1在伏隔核突触传递中的作用[J].咸宁医学院学报,2011(5):376-378. |
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| 作者姓名： | 蔡飞 王江华 吴迪 沈略 张俊杰 |
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| 作者单位： | [1]咸宁学院药学院药理学教研室,湖北咸宁437100 [2]华中农业大学水产学院 ,湖北咸宁437100 [3]咸宁学院2008-2009级本科生,湖北咸宁437100 |
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| 基金项目： | 国家自然科学基金（81000576,31000249）; 湖北省自然科学基金（2010CDZ067）; 湖北省教育厅项目（Q20112801） |
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| 摘 要： | 目的探讨PICK1蛋白在伏隔核突触传递中的作用。方法大鼠分为正常组和PICK1抑制剂（FSC231）组。采用细胞外场电位方法记录在体大鼠伏隔核基础突触传递（fEPSP）、双波异化（PPF）和输入输出曲线。结果正常组和PICK1抑制剂（FSC231）组相比,伏隔核fEPSP、PPF和输入输出曲线无显著性差异。结论抑制PICK1活性对伏隔核突触传递无明显影响。
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| 关 键 词： | PICK1 FSC231 伏隔核 突触传递 |
Effect of PICK1 on Synaptic Transmission in Nucleus Accumben |
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| Institution: | CAI Fei,WANG Jiang-hua,WU Di,et al(Department of Pharmacology,Xianning University,Xianning Hubei 437100,China) |
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| Abstract: | Objective To investigate the effect of PICK1 protein on synaptic transmission in nucleus accumbens（NAc）.Methods Male Sprague-Dawley rats were divided into two groups： normal control group and PICK1 inhibitor group（FSC231）.fEPSP,PPF and In-Out curve were recorded by in vivo electrophysiological recording in NAc.Results Compared with normal control group,fEPSP,PPF and In-Out curve had no obvious change in FSC231 group.Conclusion Inhibited the activity of PICK1 can not affect the synaptic transmission in NAc. |
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| Keywords: | PICK1 FSC231 Nucleus accumbens Synaptic transmission |
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