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Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development
Authors:Wenzhan Yang  Shobha N. Bhattachar  Phenil J. Patel  Margaret Landis  Dipal Patel  Darren L. Reid  Marieta Duvnjak Romic
Affiliation:1. Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Boston, MA 02451, USA;2. Discovery Chemistry Research and Technologies, Eli Lilly and Company, Indianapolis, IN 46285, USA;3. Small Molecule Design and Development, Eli Lilly and Company, Indianapolis, IN 46285, USA;4. Molecular Pharmaceutics, Pharmaceutical Sciences, Pfizer Global Research and Development, Cambridge, MA 02139, USA;5. Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Inc., Princeton, NJ 08543, USA;6. Pre-Pivotal Drug Product and Cellular Sciences, Drug Product Technologies, Amgen, Inc., Cambridge, MA 02142, USA;7. Technical Research & Development, Novartis Pharma AG, Basel 4002, Switzerland
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