Convalescent plasma therapy in patients with COVID-19 |
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| Authors: | Fevzi Altuntas Naim Ata Tugce Nur Yigenoglu Semih Bascı Mehmet Sinan Dal Serdal Korkmaz Sinem Namdaroglu Abdulkadir Basturk Tuba Hacıbekiroglu Mehmet Hilmi Dogu İlhami Berber Kursat Dal Kerem Kınık İbrahim Haznedaroglu Fatma Meriç Yılmaz İsa Kılıç Sinan Demircioğlu Alper Yosunkaya Osman Celik |
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| Affiliation: | 1. University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology and Bone Marrow Transplantation Center, Ankara, Turkey;2. Republic of Turkey, Ministry of Health, Department of Strategy Development, Ankara, Turkey;3. University of Health Sciences, Kayseri Training and Research Hospital, Department of Hematology, Kayseri, Turkey;4. University of Health Sciences, Bozyaka Training and Research Hospital, Department of Hematology, Izmir, Turkey;5. Selcuk University, School of Medicine, Department of Internal Medicine, Division of Hematology, Konya, Turkey;6. Sakarya University, School of Medicine, Department of Internal Medicine, Division of Hematology, Sakarya, Turkey;7. ?stanbul Training and Research Hospital, Department of Hematology, ?stanbul, Turkey;8. Inonu University, School of Medicine, Department of Internal Medicine, Division of Hematology, Malatya, Turkey;9. Kecioren Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey;10. Turkish Red Crescent, Ankara, Turkey;11. Hacettepe University, School of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey;12. Bursa City Hospital, Department of Anesthesiology, Bursa, Turkey;13. Necmettin Erbakan University, School of Medicine, Department of Internal Medicine, Division of Hematology, Konya, Turkey;14. Necmettin Erbakan University, School of Medicine, Department of Anesthesiology, Konya, Turkey;15. Nam?k Kemal University, School of Medicine, Department of Internal Medicine, Division of Hematology, Tekirda?, Turkey;p. Ankara Provincial Health Directorate, Ankara, Turkey;q. Republic of Turkey, Ministry of Health, Public Hospitals General Directorate, Ankara, Turkey;r. Ankara Y?ld?r?m Beyaz?t University, School of Medicine, Department of Hematology, Ankara, Turkey |
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| Abstract: | IntroductionPassive antibody therapy has been used to immunize vulnerable people against infectious agents. In this study, we aim to investigate the efficacy of convalescent plasma (CP) in the treatment of severe and critically ill patients diagnosed with COVID-19.MethodThe data of severe or critically ill COVID-19 patients who received anti-SARS-CoV-2 antibody-containing CP along with the antiviral treatment (n = 888) and an age-gender, comorbidity, and other COVID-19 treatments matched severe or critically ill COVID-19 patients at 1:1 ratio (n = 888) were analyzed retrospectively.ResultsDuration in the intensive care unit (ICU), the rate of mechanical ventilation (MV) support and vasopressor support were lower in CP group compared with the control group (p = 0.001, p = 0.02, p = 0.001, respectively). The case fatality rate (CFR) was 24.7 % in the CP group, and it was 27.7 % in the control group. Administration of CP 20 days after the COVID-19 diagnosis or COVID-19 related symptoms were associated with a higher rate of MV support compared with the first 3 interval groups (≤5 days, 6?10 days, 11?15 days) (p=0.001).ConclusionCP therapy seems to be effective for a better course of COVID-19 in severe and critically ill patients. |
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| Keywords: | SARS-CoV-2 Convalescent plasma COVID-19 |
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