Association of human platelet antigens polymorphisms with the levels of serum fibrosis marks in chronic hepatitis C patients |
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| Authors: | Shihang Zhou Xiaohua Liang Ni Wang Linnan Shao Weijian Yu Nan Ding Kaili Zhang Ming Liu |
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| Affiliation: | 1. Department of Blood Group, Dalian Blood Center, Dalian, China;2. Dalian Sixth People’s Hospital Affiliated of Dalian Medical University, Dalian, China;3. Department of Cell Biology, Dalian Medical University, Dalian, China;1. Unidade de Hemoterapia e Hematologia Samaritano, São Paulo, Brazil;2. Instituto de Tratamento do Câncer Infantil, University of São Paulo School of Medicine, São Paulo, Brazil;3. Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil;1. Department of Transfusion Medicine, Histocompatibility and Molecular Biology Jaypee Hospital, Sector-128, Noida, 201304, India;2. Dept of Nephrology and Renal Transplantation Jaypee Hospital, Sector-128, Noida, 201304, India;1. Australian Red Cross Lifeblood, Sydney NSW, Australia;2. Australian Red Cross Lifeblood, Brisbane QLD, Australia;1. Department of Infectious Diseases and Hunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, China;2. Department of Blood Transfusion, Xiangya Hospital, Central South University, Changsha, China;3. Laboratory of Ethnopharmacology Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, China;4. Department of PET Centre, Xiangya Hospital, Central South University, Changsha, China;1. University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology and Bone Marrow Transplantation Center, Ankara, Turkey;2. Y?ld?r?m Beyaz?t University, School of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey |
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| Abstract: | BackgroundHost genetic polymorphisms influence the fibrosis progression of chronic hepatitis C (CHC) patients. Previous studies have shown the association of human platelet antigens (HPAs) polymorphisms with CHC. However, little is known regarding the association of HPAs polymorphisms with the fibrosis progression of CHC. The aim of this study was to determine the association of HPA -2, -3, -5 and -15 polymorphisms with the levels of serum fibrosis marks in CHC patients.MethodsThe HPA -2, -3, -5 and -15 were genotyped by 5ˊ-nuclease assay in 211 CHC patients, while the serum concentration of hyaluronic acid (HA), collagen IV (CIV), amino-terminal pro-peptide of type III procollagen (PIIINP), and laminin (LN) from the same samples were measured by time resolved fluorescence immunoassay.ResultsThe level of serum LN was significantly lower in CHC patients with HPA-15aa genotype compared to those with HPA-15ab/bb (P = 0.032) but did not differ among HPA-2, -3 and -5 genotypes. There were no difference in HA, CIV and PIIINP levels among HPA-2, -3,-5 and -15 genotypes.ConclusionsThis study demonstrates that HPA-15 aa polymorphism is associated lower serum LN in CHC, which suggests that HPA -15 aa may be involved in the fibrosis progression of CHC. |
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| Keywords: | Human platelet antigen Polymorphism Chronic hepatitis C Fibrosis |
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