以葡萄糖激酶为靶点的抗糖尿病新药研究

葡萄糖激酶是糖代谢途径中的关键酶,它的异常会导致机体糖代谢紊乱而引起糖尿病等相关疾病。近年来,人们逐渐意识到以葡萄糖激酶为靶点来研究糖尿病具有极其广阔的前景。该文对葡萄糖激酶抗糖尿病的机制及其激活剂的研究现状进行了综述,提出阐明葡萄糖激酶靶点的研究及其激活剂的寻找是未来研究的方向。

The research of the glucokinase target for the treatment of diabetes

Glucokinase (GK) is considered to be the key regulatory enzyme in glucose metabolism, whose activity changing will lead to glucose metabolic disturbance and diabetes. Recently, people have realized that there is a good extensive perspective in diabetes research by means of glucokinase investigation. In this paper, we review the mechanism of diabetes resulting from abnormality of glucokinase activity and the status of glucokinase activators, propose the viewpoint that glucokinase is a powerful target for diabetes therapy and research, and illuminate that searching of glucokinase activators is the guidance in the future.