| 5-氨基酮戊酸光动力联合CO_2激光治疗尖锐湿疣对部分细胞因子的影响 |
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| 引用本文： | 杨高,梅莉红.5-氨基酮戊酸光动力联合CO_2激光治疗尖锐湿疣对部分细胞因子的影响[J].中国皮肤性病学杂志,2011,25(10). |
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| 作者姓名： | 杨高 梅莉红 |
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| 作者单位： | 上海复旦大学附属金山医院,上海,200540 |
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| 摘 要： | 目的探讨血清IL-2,IL-6,IL-8,IL-12和TNF-α的水平在尖锐湿疣免疫发病机制中的作用。方法应用ABC-ELISA法检测以5-氨基酮戊酸光动力疗法联合CO2激光治疗的35例尖锐湿疣患者治疗前、后血清中IL-2,IL-6,IL-8,IL-12和TNF-α的水平。结果治疗前尖锐湿疣患者血清中IL-6和IL-12水平低于正常对照组,但TNF-α水平高于正常对照组。治疗结束后,组内血清细胞因子水平明显较治疗前改善(P均<0.05),但治疗组和对照组的血清细胞因子水平差异均无统计学意义(P均>0.05)。结论 5-氨基酮戊酸光动力疗法联合CO2激光治疗可显著改善血清IL-6,IL-12和TNF-α水平,从而发挥其治疗作用。
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| 关 键 词： | 尖锐湿疣 光动力 白细胞介素-2 白细胞介素-6 白细胞介素-8 白细胞介素-12 肿瘤坏死因子-α |
Clinical Affcction on some Cytokines in Patients with Condyloma Acuminatum after Treatment with PDT Combine CO2 Laser |
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| YANG Gao,MEI Li-hong.Clinical Affcction on some Cytokines in Patients with Condyloma Acuminatum after Treatment with PDT Combine CO2 Laser[J].The Chinese Journal of Dermatovenereology,2011,25(10). |
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| Authors: | YANG Gao MEI Li-hong |
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| Institution: | YANG Gao,MEI Li-hong (Jinshan Hospital Attached Hospital of Fudan University,Shanghai 200540,China) |
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| Abstract: | Objective To investigate the changes of serum IL-2,IL-6,IL-8,IL-12 and TNF-α levels in patients with condyloma acuminatum(CA) before and after treatment and its role in the immune pathogenesis of CA.Methods Serum IL-2,IL-6,IL-8,IL-12 and TNF-α were detected by ABC-ELISA both before and after treatment with ALA-PDT combined CO2 Laser in 35 patients with condyloma acuminatum and 35 controls.Results The levels of seurm IL-6, IL-12 were singificantly lower in the patients than those in controls, while the serum TNF-α were significantly higher before treatment. After treatment,the levels of all serum cytokines above were changed(all P<0.05),and no significant difference with controls(P>0.05). Conclusion The levels of serum IL-6,IL-12, TNF-α can be changed significantly by PDT combined CO2 Laser |
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| Keywords: | Condyloma acuminatum PDT IL-2 IL-6 IL-8 IL-12 TNF-α |
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