炎性肠病肠道免疫学的研究进展

目的总结有关炎性肠病肠道免疫学领域的最新进展。方法采用文献复习的方法,对炎性肠病包括溃疡性结肠炎及克罗恩病免疫学领域的相关文献进行综述。结果溃疡性结肠炎和克罗恩病是炎性肠病的两种主要类型,两者的临床和病理特征既有重叠又有区别。免疫学的研究表明,易感个体对肠道微生物"过激"的炎症反应以及机体与微生物之间的相互作用在炎性肠病发生、发展中发挥重要作用。这一领域的突出成果包括发现了核苷酸结合寡聚化结构域2(NOD2)基因、自体吞噬基因、微RNA、白细胞介素23/Th17通路等。肠道细菌、肠上皮、肠道免疫细胞以及肠道微血管的功能异常在炎性肠病的病程进展中起关键作用。目前一些单克隆抗体已被用来治疗炎性肠病,并取得良好效果。结论对炎性肠病发病过程中肠道黏膜免疫基础和分子网络调控的研究,将为炎性肠病的防治提供理论依据;对炎性肠病相关基因的研究,又可为炎性肠病治疗提供更多的基因治疗靶点。

Progress of Intestinal Immunity in Inflmmatory Bowel Disease

Objective To summarize the recent progress in studies of intestinal immunity in inflammatory bowel disease(IBD). Methods The literatures on studying the intestinal immunity in IBD,including ulcerative colitis and Crohn disease were reviewed and analyzed. Results IBD comprised two main diseases that cause inflammation of the intestines: ulcerative colitis and Crohn disease.Although the diseases had some features in common,there were some important differences in clinical symptoms and pathological features.Ac...