白癜风患者血清过氧化氢、过氧化氢酶和谷胱甘肽过氧化物酶的检测

目的探讨体内氧化物和抗氧化物与白癜风发病的关系。方法分别检测40例白癜风患者和10例健康对照者的血清过氧化氢(H2O2)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-PX)。结果白癜风患者CAT浓度(9.31±6.52)U/mL明显低于对照组(33.05±9.47)U/mL,其进展期CAT浓度(7.3±6.01)U/mL明显低于稳定期(13.05±6.11)U/mL,差异均有统计学意义(P均<0.01);而白癜风患者H2O2和GSH-PX水平与对照组比较,差异无统计学意义(P>0.05)。结论白癜风的发生可能与血清氧化物—抗氧化物水平的变化有一定的相关性。

The Detection of Hydrogen Peroxide, Catalase and Glutathione Peroxide in Serum of Vitiligo

Objective To explore the relations between oxidants and antioxidants in vivo and the pathogenesis of vitiligo. Methods The hydrogen peroxide,catalase and glutathione peroxide in serum of 40 vitiligo patients and 10 healthy controls were measured. Results The catalase activities of patients,which was(9.31±6.52)U/mL,was obviously lower than that in the controls,(33.05±9.47)U/mL,and the catalase activities of active vitiligo group(7.3±6.01)U/mL was significantly lower than those of the stable vitiligo group(13.05±6.11)U/mL. The differences had statistical significance difference(all P<0.01). There were no significant difference in the hydrogen peroxide and glutathione peroxide activities between patients and controls(P>0.05). Conclusion The levels of oxidant-antioxidant in serum of patients might be associated with the pathogenesis of vitiligo.