支气管哮喘儿童外周血神经生长因子水平变化及临床意义

目的研究支气管哮喘患儿血清神经生长因子水平及临床意义。方法研究分两组,研究组72例患支气管哮喘儿童,对照组80例无喘息发作支气管肺炎患儿,抽取患儿外周血,检测其血清神经生长因子水平。结果支气管哮喘组患儿外周血神经生长因子浓度为92.6±32.5 pg/ml,轻度、中度、重度哮喘临床发作患儿血神经生长因子浓度分别为53.2±18.5 pg/ml、97.8±22.7 pg/ml、162.4±28.6 pg/ml,血清NGF水平与临床发作程度呈正相关(r=0.62;P0.05)。对照组支气管肺炎患儿外周血NGF浓度为32.8±12.6 pg/ml,低于支气管哮喘儿童外周血神经生长因子水平(P0.001)。结论支气管哮喘儿童外周血NGF明显升高,并与临床发作程度正相关。

Clinical effect and change of nerve growth factor in peripheral blood of bronchial children asthma

Objective To assess whether nerve growth factor levels are elevated in the serum in children with asthma. Methods This study included 152 children who were admitted to the pediatric department of Jingmen No. 1 People＇s Hospital. The children were di- vided into 2 groups ： Group Ⅰ , asthmatic children who had sustained an acute attack ; Group Ⅱ, children with inflammatory lung disease such as bronchopneumonia who were age and sex-matched to the diseased group. Nerve growth factor serum levels were measured in all patients by enzyme immunoassay. Results Nerve growth factor significantly increased in the 72 children with asthma（92.6± 32. 5 pg/ml） versus the 80 matched controls（ 32. 8± 12.6 pg/ml;P 〈 0. 001 ）. Furthermore, nerve growth factor levels were positive correlated to the patient＇s asthmatic attacking condition （ r = 0. 62 ;P 〈 0. 05 ）. Conclusion Nerve growth factor plays a considerable role in asthma in children.