Influence of human ceruplasmin on the aggregation of human platelets by adenosine diphosphate |
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| Authors: | J. Soria C. Soria M. Samama L. Mester |
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| Affiliation: | 1. Laboratory of Haematology, Hotel Dieu, Paris IV, C.N.R.S. Gif/Yvette, France;2. Laboratory of Biochemistry, Hopital Lariboisière, Paris X, C.N.R.S. Gif/Yvette, France;3. Institut de Chimie des Substances Naturelles, C.N.R.S. Gif/Yvette, France |
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| Abstract: | The effect of a glycoprotein, human ceruloplasmin, on the aggregation of washed human platelets induced by ADP was found to be similar to that of normal fibrinogen. Periodate oxidation and neuraminidase treatment of ceruloplasmin destroyed its ability to potentiate ADP induced platelet aggregation. Since similar observations are found with fibrinogen, it can be concluded that the glycosidic moiety of those proteins plays an important role in platelet aggregation. |
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