Dendritic cell activation is blunted in patients with coronary artery disease and diabetes mellitus |
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Authors: | Gulay Imadoglu Yetkin Aysegul Atak Yucel ?shak Özel Tekin Mustafa Y?lmaz Hakan Atalay Ertan Yetkin |
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Institution: | 1. IMC Hospital International Medical Center Division of Microbiology, Mersin, Turkey;2. Gazi University Faculty of Medicine, Department of Immunology, Ankara, Turkey;3. Zonguldak Bulent Ecevit University School of Medicine, Department of Immonology, Zonguldak, Turkey;4. Cukurova University Faculty of Medicine, Department of Pediatric Allergy and Immunology, Adana, Turkey;5. Middle East Hospital Division of Cardiovascular Surgery, Mersin, Turkey;6. Yenisehir Hospital Division of Cardiology, Mersin, Turkey |
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Abstract: | BackgroundIt has been shown that functional status of dendritic cells (DCs) in diabetic patients with unstable angina pectoris (UAP) are more mature and activated than diabetic patients without coronary artery disease (CAD) and none diabetic patients with UAP. Accordingly we aimed to assess the activation of DCs in patients with CAD with/and without Diabetes Mellitus (DM) and compare to those in subjects with normal coronary arteries (NCA).Materials and methodsTwenty three patients with severe CAD who were scheduled to coronary artery by-pass grafting surgery and 6 patients with angiographycally NCAs were included in the study. Activation of peripheral blood DCs have been analyzed by flow cytometric measures of CD86 activation.ResultsIn patients with CAD and without DM, DC activation significantly increased after stimulation of oxidesized LDL (135?±?121 vs 248?±?197 p?=?0.024). However this activation didn't significantly increased in patients with CAD and DM (100?±?20 vs 120?±?97, p?=?0,54). Patients with NCAs and without DM showed marked activation of CD86 after stimulation with ox-LDL.ConclusionWe have documented that DC activation, upon stimulation of ox-LDL has blunted in patients with CAD compared to patients with NCAs. Moreover this defective activation is more pronounced in those with diabetic patients with CAD. |
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Keywords: | Dendritic cells CD86 Atherosclerosis Diabetes mellitus Coronary artery disease |
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