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Clonally unrelated Hodgkin's disease following autologous stem cell transplant for B-cell lymphoma |
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| Authors: | Fend Falko Martinez Antonio Quintanilla-Martinez Leticia Sanz Llucia Combalia Neus Raffeld Mark Jaffe Elaine S Montserrat Emilio Campo Elias |
| Affiliation: | Department of Pathology, Technical University Munich and GSF National Research Center for Environment and Health Neuherberg, Munich, Germany. fend@lrz.tum.de |
| Abstract: | Lymphoproliferative disorders after autologous stem cell transplantation (SCT) are rare. We describe two cases of Hodgkin's disease (HD) as a late secondary neoplasia following autologous SCT for mantle cell lymphoma and B-cell chronic lymphocytic leukaemia respectively. Both HD cases were of mixed cellularity type, showed Epstein-Barr virus (EBV) positivity and followed an aggressive course. Clonal analysis of rearranged immunoglobulin genes from the primary B-cell neoplasm and the secondary HD provided evidence of separate clonal origins of the two tumours in both patients, thus excluding secondary transformation of the original B-cell clone through EBV as the causative event for development of HD. |
| Keywords: | autologous stem cell transplant Hodgkin's disease post-transplant lymphoproliferative disorder immuno-globulin gene rearrangement microdissection |
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