Prognostic significance of epidermal growth factor receptor in squamous cell carcinoma of the maxillary sinus |
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| Authors: | M. Miyaguchi S. Sakai J. Olofsson H. Kuwabara H. Sakamoto |
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| Affiliation: | (1) Department of Otolaryngology, Kagawa Medical School, Kagawa, Japan;(2) 2nd Department of Pathology, Kagawa Medical School, Kagawa, Japan;(3) Department of Otolaryngology/Head and Neck Surgery, University Hospital, Bergen, Norway;(4) Department of Otolaryngology, Kagawa Medical School, 1750-1 Miki-cho, 761-07 Kita-gun, Kagawa, Japan |
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| Abstract: | Summary The expression of epidermal growth factor receptor (EGFR) was determined immunohistochemically in two groups of maxillary sinus squamous cell carcinomas, one with recurrences at the primary site after combination therapy with radiotherapy, chemotherapy and/or surgery and one without local recurrences. Using a four-graded scale (-,+,++,+++), 9 of the 10 recurrent carcinomas had a staining intensity and proportion of stained cells of ++ or more. A comparable staining intensity was found in 9 of the 18 non-recurrent carcinomas. This difference is statistically significant (Fisher's exact probability test, P < 0.05). These results indicate that an increased expression of EGFR may influence the recurrence rate of squamous cell carcinoma of the maxillary sinus after combined therapy. |
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| Keywords: | Maxillary sinus Squamous cell carcinoma Epidermal growth factor receptor Local recurrence |
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