急性冠脉综合征早期IMA与cTnT检测的临床意义

目的探讨血清缺血修饰白蛋白及肌钙蛋白T在急性冠脉综合征早期诊断中的价值。方法选择80例急性冠脉综合征患者,其中不稳定型心绞痛组35例,心肌梗死组45例。分别于胸痛发作2、4、6、12、24h采静脉血检测其缺血修饰白蛋白及肌钙蛋白T的水平,并与正常对照组比较。结果不稳定型心绞痛和心肌梗死患者胸痛2、4h时缺血修饰白蛋白水平均明显高于正常对照组(P<0.05),而胸痛6、12、24h时缺血修饰白蛋白水平与正常对照组比较无统计学意义(P>0.05);胸痛2、4h时的缺血修饰白蛋白水平明显高于同组胸痛6、12、24h时(P<0.05);心肌梗死患者胸痛4、6、12、24h时肌钙蛋白T水平均明显高于正常对照组(P<0.01)。心肌梗死患者胸痛6、12、24h时肌钙蛋白T水平均明显高于同组胸痛4h时(P<0.01)。结论联合检测缺血修饰白蛋白及肌钙蛋白T的水平对于急性冠脉综合征早期诊断及治疗有一定临床价值。

The value of ischemia modified albumin and cardiac troponin T in early diagnosis of acute coronary syndromes

Objective To study the value of ischemia modified albumin (IMA) and cardiac troponin T (cTnT) in early diagnosis of acute coronary syndromes (ACS). Methods The 80 acute coronary syndrome patients were selected into this study among whom there were 35 patients with unstable angina and 45 patients acute myocardial infarction. The serum concentrations of IMA and cTnT were collected respectively in the 80 patients with acute coronary syndromes at 2, 4, 6, 12 and 24 hour after chest pain onset to evaluate role of them in the early diagnosis of acute coronary syndromes. Results Serum levels of IMA in patients with unstable angina and acute myocardial infarction at 2 and 4 hour after chest pain were significantly higher than those in normal controls (P<0.05); Serum levels of IMA in patients with unstable angina and acute myocardial infarction at 2 and 4 hour after chest pain were significantly higher than those at 6, 12 and 24 hour after chest pain (P<0.05). Serum levels of cTnT in patients with acute myocardial infarction at 4, 6, 12 and 24 hour after chest pain were significantly higher than those in normal controls (P<0.01); Serum levels of cTnT in patients with acute myocardial infarction at 6, 12 and 24 hour after chest pain were significantly higher than those at 4 hour after chest pain(P<0.01). Conclusion The detection of serum levels of ischemia modified albumin and cardiac troponin T has an important value in early diagnosis and treatment of acute coronary syndromes.