| 复方乳酸左氧氟沙星壳聚糖凝胶剂的制备与质量控制 |
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| 引用本文： | 王志朝,马明,刘宏,汤韧,陈鹰. 复方乳酸左氧氟沙星壳聚糖凝胶剂的制备与质量控制[J]. 中国药师, 2005, 8(3): 210-212 |
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| 作者姓名： | 王志朝 马明 刘宏 汤韧 陈鹰 |
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| 作者单位： | 广州军区武汉总医院药剂科,武汉,430070 |
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| 摘 要： | 目的:制备复方乳酸左氧氟沙星壳聚糖凝胶剂,建立其质量控制方法.方法:以壳聚糖、羧甲基纤维素为凝胶材料制备复方乳酸左氧氟沙星壳聚糖凝胶剂;采用紫外分光度法测量乳酸左氧氟沙星含量,采用容量法测定谷氨酸锌含量.结果:乳酸左氧氟沙星的线性范围为4.5～20.5 μg·ml-1,平均回收率为100.2%,RSD为0.18%(n=9).结论:该凝胶剂制备工艺简单,质量控制方法可靠,质量稳定.
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| 关 键 词： | 左氧氟沙星,乳酸 谷氨酸锌 壳聚糖 凝胶剂 质量控制 |
| 文章编号： | 1008-049X(2005)03-0210-03 |
| 修稿时间： | 2004-02-25 |
Preparation and Quality Control of Compound Levofloxacin Lactate Chitosan Gel |
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| Wang Zhichao,Ma Ming,Liu Hong,TANG Ren,Chen Ying. Preparation and Quality Control of Compound Levofloxacin Lactate Chitosan Gel[J]. China Pharmacist, 2005, 8(3): 210-212 |
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| Authors: | Wang Zhichao Ma Ming Liu Hong TANG Ren Chen Ying |
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| Abstract: | Objective: To prepare the compound levofloxacin lactate and chitosan gel and establish a method for the quality control of this gel. Method: Carboxyl methylcellulose and chitosan were used to prepare compound levofloxacin lactate gel, the content of levofloxacin lactate was detemined by spectrophotometry, the content of zinc glutamate was assayed by volumetry. Result: The preparing method was simple and the quality control was reliable, the quality of preparation was stable. Conclusion: The quality of this preparation accords with relevant regulations of gel preparation in China pharmacopoeia. |
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| Keywords: | Levofloxacin lactate Zinc glutamate Chitosan Gel Quality control |
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