Xenon - noble gas with organprotective properties |
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Authors: | Preckel B Weber N Schlack W |
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Institution: | Klinik für An?sthesiologie, Universit?tsklinikum Düsseldorf. preckel@med.uni-duesseldorf.de |
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Abstract: | Besides it's anaesthetic properties, xenon may induce biological effects that may protect various organs from ischaemia-reperfusion injury. Xenon is an antagonist of the NMDA-receptor and reduces the neuronal injury mediated via these receptors. In contrast to other NMDA-receptor antagonists, xenon has no neurotoxic side effects. Xenon also protects the heart in ischaemia-reperfusion situations. Xenon reduces the post-ischaemic reperfusion injury and offers cardioprotection by inducing pharmacological preconditioning. These organ protective properties of xenon might be useful in special clinical situations. |
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