| 慢性白血病抗原CML28 HLA-A*0201限制性CTL表位预测 |
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| 引用本文： | 韩俊锋,吴玉章,林治华,万瑛,何仰东.慢性白血病抗原CML28 HLA-A*0201限制性CTL表位预测[J].免疫学杂志,2004,20(4):256-258. |
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| 作者姓名： | 韩俊锋 吴玉章 林治华 万瑛 何仰东 |
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| 作者单位： | 第三军医大学基础部全军免疫研究所,重庆,400038 |
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| 基金项目： | 国家“973”计划资助项目 (2 0 0 1CB51 0 0 0 1 ) |
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| 摘 要： | 目的鉴定慢性白血病肿瘤抗原CML28的HIA-A*0201限制性CTL表位。方法 采用超基序和量化基序结合的方法初步预测CM128的HLA-A*0201限制性CTL表位；利用T2细胞亲合力实验初步验证预测结果。结果 在预测的4个候选CTL表位中，ALVDAGVPM和ALDSDGTLV有较高的亲和力，ALFCGVACA和SLLACCLNA仅有低度亲和力。结论ALVDAGVPM与ALDSDGTLV最有可能是慢性白血病肿瘤抗原CML28的HLA-A*0201限制性CTL表位。
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| 关 键 词： | 肿瘤抗原 CML28 CTL表位 预测 |
| 文章编号： | 1000-8861(2004)04-0256-03 |
| 修稿时间： | 2004年5月14日 |
Identification of HLA-A * 0201-restricted cytotoxic T lymphocyte epitope from CML28 |
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| HAN Jun-feng,WU Yu-zhang,LIN Zhi-hua,WAN Ying,HE Yang-dong.Identification of HLA-A * 0201-restricted cytotoxic T lymphocyte epitope from CML28[J].Immunological Journal,2004,20(4):256-258. |
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| Authors: | HAN Jun-feng WU Yu-zhang LIN Zhi-hua WAN Ying HE Yang-dong |
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| Abstract: | Objective To identify HLA-A*0201-restricted CTL epitopes from chronic myelocytic leukemia tumor antigen CML28. Methods The HLA-A*0201-restricted CTL epitopes from chronic myelocytic leukemia tumor antigen CML28 were predicted by quantitative motif method. Then the prediction was evaluated by T2 binding test. Results The results revealed that the two peptides (ALVDAGVPM and ALDSDGTLV) had a higher affinity for HLA-A*0201 molecule than that the other two peptides (ALFCGVACA and SLLACCLNA) had. Conclusion Peptides ALVDAGVPM and ALDSDGTLV may be the HLA-A*0201 restricted CTL epitopes of CML28. |
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| Keywords: | Cancer antigen CML28 CTL epitope Prediction |
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