| Different Effects of Topical Prazosin and Pilocarpine on Uveoscleral Outflow in Rabbit Eyes |
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| 作者姓名： | Jianming Wang~ Yanping Song~ Baichao Ren~ Naixue Sun~ Yinggui Yu~ Haitao Hu~ |
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| 作者单位： | Jianming Wang~1，Yanping Song~2，Baichao Ren~1，Naixue Sun~1，Yinggui Yu~1，Haitao Hu~1 1 Department of Ophthalmology，The Second Hospital，Xi'an Jiaotong University，Xi'an 710004，China 2 Department of Hematology，The Center Hospital of Xi'an City，Xi'an 710003，China |
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| 基金项目： | This study is supported by Chinese Natural Science Foundation (No.39370724) |
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| 摘 要： | Purpose:To investigate the effects of topical prazosin and pilocarpine on uveoscleral outflow(Fu) in rabbits.Methods:Sixteen rabbits were randomly divided into the control group (5 rabbits, only topical application of normal saline in the fight eye of each rabbit), Prazosin (PZ) treated group (6 rabbits, only 0.1％ Prazosin eyedrop 0.1％ in the right eye of each one) and Pilocarpine (PC) treated group (5 rabbits, 1％ Pilocarpine eye drop in each fight eye). Intraocular pressure (IOP) of bilateral eyes of each rabbit was measured before and 1h after topical application of the eye drop. And the bilateral eyes were perfused with Fluorescein-isothiocyanate bovine serum albumin (FITC-BSA) as the tracer into the anterior chamber of each rabbit for 30 min at 90 min after topical treatment. Then the rabbits were killed for Fu measurement.Results:IOP of PZ-treated eyes decreased (0.71±0.07)kPa] in 1 hour after PZ application. IOP of PC-treated eyes decreased (0.70±0.08)kPa] in 1 hour after PC application. Th
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| 关 键 词： | 哌唑嗪 匹鲁卡品 局部用药 葡萄膜巩膜炎 |
Different Effects of Topical Prazosin and Pilocarpine on Uveoscleral Outflow in Rabbit Eyes |
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| Jianming Wang,Yanping Song,Baichao Ren,Naixue Sun,Yinggui Yu,Haitao Hu .Different Effects of Topical Prazosin and Pilocarpine on Uveoscleral Outflow in Rabbit Eyes[J].Eye Science,2003,19(3):191-194. |
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| Authors: | Jianming Wang Yanping Song Baichao Ren Naixue Sun Yinggui Yu Haitao Hu |
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| Institution: | 1. Department of Ophthalmology, The Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China
2. Department of Hematology, The Center Hospital of Xi'an City, Xi'an 710003, China |
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| Abstract: | PURPOSE: To investigate the effects of topical prazosin and pilocarpine on uveoscleral outflow (Fu) in rabbits. METHODS: Sixteen rabbits were randomly divided into the control group (5 rabbits, only topical application of normal salino in the right eye of each rabbit), Prazosin (PZ) treated group (6 rabbits, only 0.1% Prazosin eyedrop 0.1% in the right eye of each one) and Pilocarpine (PC) treated group (5 rabbits, 1% Pilocarpine eye drop in each right eye). Intraocular pressure (IOP) of bilateral eyes of each rabbit was measured before and 1 h after topical application of the eye drop. And the bilateral eyes were perfused with Fluorescein-isothiocyanate bovine serum albumin (FITC-BSA) as the tracer into the anterior chamber of each rabbit for 30 min at 90 min after topical treatment. Then the rabbits were killed for Fu measurement. RESULTS: IOP of PZ-treated eyes decreased (0.71 +/- 0.07)kPa] in 1 hour after PZ application. IOP of PC-treated eyes decreased (0.70 +/- 0.08)kPa] in 1 hour after PC application. The average value of Fu was (0.176 +/- 0.048) microliter/min in control eyes. The average value of Fu in PZ-treated eyes was (0.339 +/- 0.018) microliter/min. The average value of Fu in PC-treated eye was (0.123 +/- 0.022) microliter/min. CONCLUSION: Both of PZ and PC can decrease IOP in rabbits following topical application. Topical PZ can increase Fu in rabbits and this is one of the mechanisms of PZ-induced IOP decrease. Topical PC can prevent Fu. PC decreases IOP not through uveoscleral pathway. This study demonstrates that uveoscleral pathway plays an important role in aqueous humor drainage. PZ may be a novel drug for decreasing IOP. FITC-BSA is an effective tracer for studying uveoscleral pathway. |
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| Keywords: | uveoscleral outflow prazosin pilocapine FITC-BSA |
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