血清流行病学现场调查免疫酶法实用价值的研究

我们用免疫酶法对湖南省鼻咽癌高发区及低发区现场人群共计104200名进行了EB病毒VCA-IgA抗体普查,检出鼻咽癌的灵敏度为88.5%,特异度99.2%,现场阳性试验的诊断价值为2.63%,这比从临床应用免疫酶法诊断鼻咽癌的结果(灵敏度89.2%,特异度83.3%)来推算现场阳性试验的诊断价值(0.11%)高约24倍,证明该法直接用于现场普查大规模人群比临床应用具有更大的实用价值和优越性。

A Study of the Practical Value on the Immunoenzyme Method in the Seroepidemiological Field Survey

This paper reports the serological survey using immunoenzyme method of EB virus VCA-IgA antibody of a total of 104,200 people in high and low nasopharyngeal carcinoma (NPC) incidence regions in Hunan Province. The sensitivity and specificity of detecting NPC in field survey are 88.5% and 99.2% respectively. The diagnostic value of the field positive test is 2.63%. It is about 24 times higher than the value obtained by presumption from the sensitivity (89.2%) and specificity (83.3%) of this method used in clinical diagnosis of NPC.Therefore the immunoenzyme method directly applied to survey a large size of population in epidemiological field is more practically valuable and advantageous as compared with the clinical application.