多西紫杉醇联合顺铂、5-氟尿嘧啶化疗治疗进展期胃癌的48例疗效观察

目的探讨多西紫杉醇、顺铂、5-氟尿嘧啶的联合化疗方案对进展期胃癌的疗效和毒副作用。方法自2007年1月至2008年12月共有48例进展期胃癌患者入组本次临床研究。化疗方案为：多西紫杉醇75mg/m^2,第1天;顺铂25mg/m^2,第1～3天;5-氟尿嘧啶500mg/m^2,持续滴入或泵入（第1～5天）,每3周为1个周期,共2个周期。观察化疗后肿瘤原发病灶的变化情况及化疗的毒副反应。结果临床有效率为62.5%,其中完全缓解（CR）2例,部分缓解（PR）28例,疾病稳定（SD13例）,疾病进展（PD）5例。毒副作用主要是白细胞减少、腹泻、恶心、呕吐、脱发,但未有因此而死亡的病例。结论多西紫杉醇加顺铂及5-氟尿嘧啶的联合化疗方案是治疗进展期胃癌有效安全的方法之一。

The effect of united chemotherapy of docetaxel,cisplatin and fluorouracil on 48 patients with advanced gastric carcinoma

Objective To evaluate the efficacy and toxicity of docetaxelplus cisplatin plus fluorouracil （DCF） on advanced gastric carcinoma （AGC）. Methods From Octobe 2007 to 2008,48 cases of AGC patients were treated with DCF regimens. Chemotherpy regimens containing docetaxel（D） ,75 mg/m^2 （dayl） plus cisplatin （C） ,25 mg/m^2, VD, （ dayl-3 ） plus fluorouracil （F） 500 mg/m^2 VD 24 hours （ dayl-5 ）, were admin- istered every 3 weeks for two cycles. There sponse in the primary tumor and the toxicity were observed. Results There sponse in the primary tumor：clinical efficacy rate was 62.5% （2 CR and 28 PR,13 SD and 5PD）. The most common toxicity were leukocytopenia, nausea/vomiting and alopcia. Conclusion The regimens of docetaxel plus cisplatin plus fluorouracil is an effctive and well-tolerated method on cure the patients with AGC.