Antiviral Activity of 3-Methyleneoxindole |
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| Authors: | V. Tuli H. S. Moyed D. Stevenson I. Gordon |
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| Affiliation: | .Department of Medical Microbiology, College of Medicine, University of California, Irvine, California 92664;.Department of Microbiology, University of Southern California School of Medicine, Los Angeles, California 90033 |
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| Abstract: | 3-Methyleneoxindole (MO), an oxidation product of the plant auxin indole-3-acetic acid, can selectively inhibit the replication of herpes-, mengo-, polioviruses, and Sindbis virus. The antiviral action of MO, a sulfhydryl binding compound, is neutralized by 2-mercaptoethanol if the latter is added soon after exposure of infected cells to MO. If addition of 2-mercaptoethanol is delayed, the antiviral action of MO appears to be irreversible. Data are presented which indicate that the antiviral action of MO is not mediated by interferon. |
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