大肠癌中 CXCR4、MMP-2 的表达与血管新生及肿瘤转移的临床意义

目的：观察趋化性细胞因子受体CXCR4、基质金属蛋白酶MMP-2在大肠癌中的表达及其与血管新生的关系及其临床意义。方法：用免疫组化法检测56例大肠癌、10例癌旁组织中CXCR4、MMP-2的表达，用血管VIII因子标记血管内皮细胞计数微血管密度，分析CXCR4和MMP-2表达与MVD及临床病理特征的关系。结果：56例大肠癌组织CXCR4阳性率64．3％，10例癌旁组织中阳性率20％，差异有显著性意义。56例大肠癌组织MMP-2阳性率78．5，10例癌旁组织阳性率30％，差异有显著性意义。CXCR4和MMP-2的表达与大肠癌患者的临床分期、淋巴结转移和MVD密切相关。结论：CXCR4和MMP-2在大肠癌中的表达明显升高，可能与大肠癌血管生成和肿瘤转移有关。

Expression of CXCR4 and MMP-2 in colorectal cancer and their relationship with microvessel density and tumor metastasis

Objective:To investigate the expression of chemokine receptor CXCR4 and of matrix metalloproteinase MMP-2 and analyse the relationship among the expression of CXCR4,MMP-2 and microvessel density,the clinic pathological diameters in colorectal cancer.Methods:The expression of CXCR4 and MMP-2 in 56 colorectal cancers and 10 normal colorectal specimens was evaluated by immunohistochemistry.VIII immunostaining was used to measure the microvessel density.The correlation among the the expression of chemokine receptor CXCR4,MMP-2 and MVD,the clinical pathological diameters was evaluated.Results:CXCR4-positive expression was 64.3%(36/56) in colorectal cancers,20%(2/10) in normal colorectal tissues,expression was 78.5%(44/56) in colorectal cancers,30%(3/10) in normal colorectal tissues.However,the expression of CXCR4 and MMP-2 were relevant to clinical stage,lymph node metastasis and MVD.Conclusion:The expression of CXCR4 and MMP-2 was distinctly higher in colorectal cancers.CXCR4 and MMP-2 may promote the angiogenesis and the metastasis in colorectal cancer.