紫藤瘤化学成分研究

目的研究紫藤瘤(Wisteria sinensis Sweet Caulis)化学成分。方法紫藤瘤(15 kg)95%乙醇渗漉液的石油醚萃取部位,经过硅胶、Sephadex LH-20等多种材料进行分离纯化,通过波谱技术进行结构鉴定。结果从95%乙醇提取物的石油醚萃取部位中分离鉴定了6个化合物,分别为蒲公英赛醇(1),蒲公英赛酮(2),木栓酮(3),表木栓醇(4),β-谷甾醇(5),β-胡萝卜苷(6)。结论化合物1～6均为首次从该种中分得。

Effects of curcumin solid dispersions on blood lipid metabolism in mice

Objective To study the effects of curcumin solid dispersions on lipid metabolism in hyperlipidemia mice.Methods Kunming male mice were fed with high fat emulsion,then grouped at random and orally administered with curcumin solid dispersions or pure curcumin suspension.The level of serum total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C） were determined to find the difference between curcumin solid dispersions group and pure curcumin suspension group.Sixty-six Kunming male mice were grouped at random,then orally administered with curcumin solid dispersions or pure curcumin suspension at the same dosage.The mice were killed at diffetent time and blood collected to test the plasma concentration of curcumin.Results Compared with pure curcumin,curcumin solid dispersions could significantly reduce the content of TC,TG,and LDL-C in serum,get elevate the serum HDL-C level.The time-concentration curve indicated that the Cmax and AUC of curcumin solid dispersions were far greater than pure curcumin.Conclusion Curcumin solid dispersions which is superior to pure curcumin has an obviously lipid-lowering effect on experimental hyperlipidemia mice.Solid dispersions could increase the absorption and bioavailability of curcumin in vivo.