血清胱抑素C和尿微量白蛋白/肌酐比值在高血压肾损害早期诊断中的意义

目的:探讨血清胱抑素C(Cys C)和尿中微量白蛋白(mAlb)与肌酐(Cr)比值对诊断高血压早期肾损害的临床价值。方法:选择尿蛋白阴性的原发性高血压患者65例,以健康体检人群58名为对照,采用免疫透射比浊法测定血清Cys C含量,免疫浊度法测定尿mAlb含量,全自动生化分析仪同时测定血清Cr和尿Cr。结果:高血压组的Cys C与尿mAlb/Cr测定结果均明显高于对照组(P0.01)。而血Cr在2组中差异无统计学意义(P0.05)。结论:尿蛋白定性阴性不能排除肾脏的早期损伤,联合检测血Cys C与尿mAlb/Cr指标,对高血压早期肾功能损害诊断的敏感性和特异性更高。

The significance of serum cystatin C and ratio of urine microalbumin to creatinine for diagnosing early renal impairment in patients with hypertension

Objective:To evaluate the applicability of serum cystatin C(Cys C) and ratio of urine microalbumin(mAlb) to creatinine(Cr) for diagnosing early renal impairment in patients with hypertension.Methods:The concentration of serum Cys C was measured by immune transmission nephelometry and urine mAlb was measured by immune turbidimetry method and the concentration of serum Cr and urine Cr were measured by automatic chemisty analyzer in 65 cases of hypertension patients and 58 cases of health adults.Results:The concentration of Cys C and ratio of urine mAlb to Cr in hypertension group were higher than those in health control group,and there had statistical differences between the two groups(P<0.01),but no statistical significance about the concentration of serum Cr(P>0.05).Conclusions:The negative result of qualitative urine protein can not exclude early renal impairment.Through serum Cys C and urine mAlb/Cr index detection,there has the higher sensitivity and specificity for diagnosing early renal damage with hypertension.