| 高效液相色谱法测定去甲斑蝥酸钠注射液含量及有关物质 |
| |
| 引用本文： | 杜宁.高效液相色谱法测定去甲斑蝥酸钠注射液含量及有关物质[J].北方药学,2012,9(1):7-8. |
| |
| 作者姓名： | 杜宁 |
| |
| 作者单位： | 江苏省食品药品检验所,南京,210008 |
| |
| 摘 要： | 目的:建立去甲斑蝥酸钠注射液含量HPLC 及有关物质的测定方法.方法:以C18 柱,0.1mol·L-1磷酸氢二钾溶液-乙腈(80∶20)(磷酸调节pH 值至2.6)为流动相,流量为1.0ml·min-1,柱温30℃.检测波长为210nm.结果:在浓度为20.00～200.04μg·mL-1范围内,本法线形关系良好,相关系数r＝0.9997(n=7).结论:该方法简单,准确,可以作为去甲斑蝥酸钠注射液含量和有关物质的测定方法.
|
| 关 键 词： | 去甲斑蝥酸钠注射液 含量测定 有关物质 HPLC |
Determination of Sodium Demethylcantharidate Injection and its Related Substances by HPLC |
| |
| Du Ning.Determination of Sodium Demethylcantharidate Injection and its Related Substances by HPLC[J].BEIFANG YAOXUE,2012,9(1):7-8. |
| |
| Authors: | Du Ning |
| |
| Institution: | Du Ning(Jiangsu Institute for Food and Drug Control, Nanjing 210008, China) |
| |
| Abstract: | Objective： To develop a HPLC method of determinating of sodium demcthyleantharidate injection and its related substances. Methods： The determination was carried out on a C18 column. The mobile phase was 0.1mol ·L^-1 dipotassium hydrogen phosphate solutionacetonitrile （80.20）（adjusted pH to 2.6 with phosphoric acid）with flow rate of 1.0 ml·min^-1 and the column temperature was 30℃. The detection wave-length was 210nrn. Results： There was a good linearty over the range of 20.00-200.04μg ·mL^-1 with a coefficient of eorrelation（r）0.9997（n=7）. Conclusion： The method was simple and accurate, it can be used as a method of qu＇,flity control . |
| |
| Keywords: | Sodium demethylcantharidate injection Determination Related substances HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
