Comparative in vitro activity of LY146032 (Daptomycin) against gram-positive cocci

The in vitro activity of LY146032 was compared with those of seven other antimicrobial agents against gram-positive cocci. MICs of LY146032 were lowest forStreptococcus pneumoniaeand methicillin-susceptibleStaphylococcus epidermidis (0.25 mg/l).For methicillin-resistantStaphylococcus epidermidisandStaphylococcus aureusthe MICs were 1 mg/l, forEnterococcus faecalis2 mg/l and forEnterococcus faecium4 mg/l. The activity of LY146032 was in general higher than that of vancomycin. Time-kill studies showed LY146032 had higher bactericidal activity than vancomycin against a methicillin-resistantStaphylococcus aureusstrain, and bactericidal activity againstEnterococcus faecalisandEnterococcus faecium.