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Coumarins as inhibitors of bacterial DNA gyrase |
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| Authors: | I W Althaus L Dolak F Reusser |
| Affiliation: | Upjohn Company, Kalamazoo, MI 49001. |
| Abstract: | Chlorobiocic acid and 3-(carbobenzoxyamino)-4,7-dihydroxy-8-methylcoumarin were identified as two new inhibitors of Micrococcus luteus DNA gyrase. Both compounds possess weak antibacterial activity against whole M. luteus cells which indicates that they probably lack efficient transport functions to penetrate the cell envelope. |
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