Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease |
| |
| Authors: | Bastos Jessica A Diniz Cláudio G Bastos Marcus G Vilela Eduardo M Silva Vânia L Chaoubah Alfredo Souza-Costa Debora C Andrade Luiz Carlos F |
| |
| Affiliation: | aPostgraduate Program in Health – Concentration Area, Brazilian Health, Federal University of Juiz de Fora, MG, Brazil;bDepartment of Parasitology, Microbiology and Immunology, Federal University of Juiz de Fora, MG, Brazil;cInterdisciplinary Center for Studies, Research and Treatment in Nephrology (NIEPEN), Federal University of Juiz de Fora, MG, Brazil;dDepartment of Stomatology, Federal University of Juiz de Fora, MG, Brazil;eDepartment of Statistics, Federal University of Juiz de Fora, MG, Brazil |
| |
| Abstract: | ObjectiveIn this study of patients with chronic periodontitis (CP), the severity of the disease and the main periodontal pathogens identified in patients with chronic kidney disease (CKD) were compared with those detected in individuals without systemic disease.DesignNineteen patients with CP without evidence of systemic disease (control group), 25 patients with CP and CKD who were in the pre-dialysis stages (pre-dialysis group), and 22 patients with CP and CKD who were on renal replacement therapy (RRT group) were examined. The severity of CP was based on the investigation of probing depth (PD) and clinical attachment level (CAL). The definition and stage of CKD were based on the criteria proposed by the Kidney Disease Outcomes Quality Initiative of the National Kidney Foundation. Glomerular filtration rate (GFR) was estimated using the equation of Modification of Diet in Renal Disease and the identification of microorganisms in subgingival plaque was performed using polymerase chain reaction (PCR).ResultsCandida albicans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were more common in patients who were on RRT and pre-dialysis than in control subjects. CP was more severe in patients with CKD. A strong association was observed between the frequency of C. albicans (P = 0.056), P.gingivalis (P = 0.008), T. denticola (P = 0.013) and CAL, when CKD patients were compared with the control group.ConclusionCP is more severe and is associated with increased frequency of C. albicans, P. gingivalis, T. forsythia, and T. denticola in patients with CKD. |
| |
| Keywords: | Periodontal disease Periodontal pathogens Oral microbiota Chronic kidney disease Polymerase chain reaction |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
