| 耳用地塞米松热敏性凝胶的制备及性能的检测 |
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| 引用本文： | 王勤,程雪峰,李聪,顾健,敖华飞. 耳用地塞米松热敏性凝胶的制备及性能的检测[J]. 医学综述, 2014, 20(19): 3593-3595 |
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| 作者姓名： | 王勤 程雪峰 李聪 顾健 敖华飞 |
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| 作者单位： | 上海交通大学医学院附属第三人民医院耳鼻咽喉-头颈外科,上海,201900 |
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| 摘 要： | 目的制备耳用地塞米松热敏性凝胶,并对其体外释放性能进行检测。方法制备以泊洛沙姆407为载药基质的地塞米松热敏性凝胶,根据适用于接近中耳温度的34℃作为筛选标准,选择最佳处方浓度的泊洛沙姆407,并对体外释放性能进行研究。结果地塞米松检测浓度的线性范围为4.024.0 mg/L,在该范围内吸光度(A)和浓度(C)呈良好的线性关系,即C(mg/L)=44.241A-1.860(r=0.998,n=6);其平均回收率为100.43%,RSD=0.848%(n=6);泊洛沙姆407最佳处方浓度为17%;药物释放具有一定的缓释性,释放过程符合零级动力学方程。结论该耳用地塞米松热敏性凝胶具有缓释性能,整个制备过程简便,极具开发前景。
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| 关 键 词： | 地塞米松 泊洛沙姆407 热敏型耳用凝胶 体外释放 |
Preparation of Dexamethasone Thermosensitive Otic Gel and Test for Its Characteristics |
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| WANG Qin,CHENG Xue-feng,LI Cong,GU Jian,AO Hua-fei. Preparation of Dexamethasone Thermosensitive Otic Gel and Test for Its Characteristics[J]. Medical Recapitulate, 2014, 20(19): 3593-3595 |
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| Authors: | WANG Qin CHENG Xue-feng LI Cong GU Jian AO Hua-fei |
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| Affiliation: | 1.Department of Otolaryngology-Head and Neck Surgery, the Third People＇s Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 201900, China;) |
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| Abstract: | |
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| Keywords: | Dexamethasone Poloxamer 407 Thermosensitive gel for otitis drug delivery Release in vitro |
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