IL-17家族及其在支气管哮喘发病中的作用

支气管哮喘(哮喘)是一种儿童时期最常见的慢性炎症性疾病,目前的发病机制尚未完全明确。近年来,一种新型细胞Th17分泌的以白细胞介素17为主的细胞因子在哮喘的发生、发展中发挥着重要的作用,它既介导哮喘中性粒细胞性呼吸道炎症,也与呼吸道重塑和呼吸道高反应密切相关,这一发现能更深入地了解哮喘的发病机制,而且如果能作为诊疗手段的突破口,将对儿童哮喘治疗进展产生重大影响。

Study on IL-17 Family and Its Role in the Pathogenesis of Asthma

Bronchial asthma （asthma） is the most common chronic inflammatory disease of children,although the pathogenesis remains unclear at present.In recent years,it has been found that cytokine（mainly is IL-17） secreted by Th17 cells,a new kind of cells,plays an important role in the incidence and progression of asthma.It can not only mediate neutrophilic airway inflammation,but also has close relationship with airway remodeling and airway hyperresponsiveness,which can help us deeply understand the pathogenesis of asthma.Taking it as a breakthrough of the treatment for asthma may have significant impact on the treatment for childhood asthma.