重复经颅磁刺激结合艾司西酞普兰治疗抑郁症临床研究

目的：探讨重复经颅磁刺激（rTMS）结合艾司西酞普兰治疗抑郁症的临床疗效.方法：将68例首发抑郁症患者随机分为对照组和观察组各34例,观察组采用重复经颅磁刺激结合艾司西酞普兰治疗,对照组采用艾司西酞普兰治疗.治疗时间为8周,于8周末评价其疗效,评价指标采用24项汉密顿抑郁量表（HAMD-24）评定.观察各量表评分相对基线值的变化情况.结果：治疗前rTMS结合艾司西酞普兰组HAMD评分（32.67±6.52）分]与艾司西酞普兰组（30.88±6.60）分]的差异无统计学意义（t=1.127,P=0.264）;治疗第8周末,rTMS结合艾司西酞普兰组23例治愈,8例好转,3例无效;艾司西酞普兰组16例治愈,9例好转,9例无效.两组疗效差异有统计学意义（F=7.843,P=0.005）.治疗后rTMS结合艾司西酞普兰组HAMD评分（12.20±8.97）分]与艾司西酞普兰组（19.35±11.43）分]的差异有统计学意义（t=-2.87,P=0.006）.结论：重复经颅磁刺激结合艾司西酞普兰治疗抑郁症患者效果明显,值得临床推广应用.

Repetitive Transcranial Magnetic Stimulation Combined with Escitalopram Treatment of Depression

Objective：To discuss repetitive transcranial magnetic stimulation （rTMS） combined with escitalopram treatment the clinical curative effect of patients depression. Methods： Randomly 68 patients with first-episode depression divided into control group and observation group, the observation group use the rTMS combined with escitalopram ,and the control group adopts escitalopram treatment . After treating 8 W, evaluate its curative effect in 8 weekends, evaluation index with 24 counts of Hamilton depression scale （HAMD - 24）. Observe the changes of the rating scale relative to the baseline value. Results：Former rTMS treating combined between escitalopram group of HAMD score -（32.67±6.52）] and escitalopram group （30.88±6.60）] had no statistically signifi- cant （t= 1. 127, P=1. 127） ; treated 8 weekends, rTMS combined with escitalopram citalopram group 23 cases were cured, 8 cases were improved, 3 cases ineffective; escitalopram group of 16 cases were cured, 9 cases were improved, 9 cases of invalid. The differ- ence of the two groups had statistically significant （F= 7. 843, P = 0. 005） . After treated the rTMS combined with escitalopram group of HAMD score -（12. 202±8.97）] and escitalopram group E（19. 35±11. 43）] there difference had statistically significant （t= 2.87,P=0. 006） . Conclusion： The repetitive transcranial magnetic stimulation combined with escitalopram treatment of patients with depression effect is obvious, and worthy of promotion.