甲状腺功能亢进的糖尿病患者生化指标变化

目的：观察合并甲状腺功能亢进(甲亢)的2型糖尿病(type 2 diabetes mellitus,T2DM)患者的生化指标变化,探讨甲亢对 T2DM 患者的影响。方法回顾性分析72例 T2DM 合并甲状腺功能异常的患者(甲亢组)与140例 T2DM 甲状腺功能正常患者(对照组)的血糖、血脂、肾功能等变化。结果与对照组比较,甲亢组甘油三脂、总胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、肌酐降低,而两组空腹血糖、餐后两小时血糖、高密度脂蛋白胆固醇、极低密度脂蛋白及尿白蛋白/肌酐、肾小球滤过率差异均无统计学意义。结论伴有甲亢的 T2DM 患者虽然个别指标降低,但在糖代谢紊乱、肾脏损伤、大血管并发症方面有着同样的风险,治疗上应予以重视。

Biochemical parameters change in diabetic patients with hyperthyroidism

Objective To observe the biochemical markers of type 2 diabetes mellitus（T2DM）patients with hyperthyroidism,to investigate the effects of hyperthyroidism in patients with T2DM.Methods Retrospective analysis was performed in blood sugar,blood lipid,renal function and other indicators of 72 T2DM cases with thyroid function abnormality（hyperthyroidism group）and 140 T2DM with normal thyroid function （control group）.Results Compared with the control group,triglyceride,total cholesterol,low density lipoprotein cholesterol,glycated hemoglobin, creatinine in hyperthyroidism group decreased, while there were no significant difference in fasting glucose, postprandial blood glucose two hours,high density lipoprotein cholesterol,very low density lipoprotein and urinary albumin/creatinine between two groups.Conclusion Although individual indicators in T2DM cases with thyroid function abnormality decreased,the patients share similar risk in glucose metabolism disorders,kidney damage, vascular complications,and attention should be paid on the treatment.