太原市孕期妇女体内多环芳烃负荷水平及影响因素研究

目的了解太原市孕期妇女体内多环芳烃暴露水平，探讨多环芳烃暴露的影响因素。方法2006年10月至2008年1月，抽取太原市某两所医院住院分娩孕妇347人，收集产前尿样，利用高效液相色谱-荧光检测法测定尿样1-羟基芘（1-OHPy）水平，并针对生活环境情况进行问卷调查。结果共240名孕妇的尿样符合检测条件，尿样1-OHPy检出率为93．8％，检出浓度中位数为0．794μmol／molCr（P25：0．519μmol／molCr,P25：1．369μmol／molCr）。厨房卧室未分开、做饭时未使用抽油烟机、中学及以下教育程度的孕妇，其尿样1-OHPy含量较高（P〈0．05）。多元线性回归分析显示，孕妇每周烹调时间、被动吸烟和取暖方式是影响孕妇尿样1-OHPy水平的主要因素。结论太原市孕期妇女多环芳烃暴露水平偏高，室内空气污染和行为生活方式在孕期妇女多环芳烃暴露中起着重要的作用。

Study on levels and the influencing factors of PAHs among the pregnant women in Taiyuan City

Objective To study the present levels of polycyelic aromatic hydrocarbons （PAHs） among the pregnant women in Taiyuan City, and to explore the influencing factors related to PAHs exposure. Methods 347 pregnant women from 2 hospitals in Taiyuan Ctiy was investigated during the period of October 2006 to January 2008. High-performance liquid chromatography （HPLC） with subsequent fluorescence detection was used to determine the urine 1 -Hydroxy- pyrene, and questionnaire survey was conducted to obtain individual behavior and lifestyle. Results 240 urine samples was valid. The percentage of the 1 - OHPy detectable samples was 93.8%. 1 - OHPy concentration was 0. 794μmol/mol Cr （median） and IQR was 0. 519 - 1. 369μmol/mol Cr. The influencing factors related to the 1 - OHPy concentration included education level, usage of cooking fume extractor and the kitchen separated from the living room. Cooking frequencies, passive smoking and residential heating were the independent factors to the 1 - OHPy level after controlling the other confounders in multiple linear regression models. Conclusion Pregnant women in Taiyuan City exposed to high PAHs. Indoor air pollution and individual behavior, lifestyles play an important role in the high PAHs exposure.